Novel Technologies for Live

Our aim is to understand the dynamic regulatory networks that drive cellular functions. Using multidimensional approach our pursuit is to understand the coordination within biological systems, shedding light on the resilience and adaptability or lite forms in the face or biotic and abiotic stresses. By delving into genomics, proteomics, and metabolomics, combined with machine learning and data analysis, we uncover the orchestration of biological processes essential for survival and adaptation.

Publications

Brychkova, G., McGrath, A., Larkin, T., Goff, J., McKeown, P. C., & Spillane, C. (2024). Use of anaerobic digestate to substitute inorganic fertilisers for more sustainable nitrogen cycling. Journal of Cleaner Production, 446, 141016. doi:https://doi.org/10.1016/j.jclepro.2024.141016

Hallahan, B. F., Quiroz, L. F., Brychkova, G., McKeown, P. C., & Spillane, C. (2024). Accession-specific parent-of-origin dependent and independent genome dosage effects on salt tolerance in <i>Arabidopsis thaliana</i>. Royal Society Open Science, 11(5), 231766. doi:10.1098/rsos.231766

Quiroz, L., Ciosek, T., Grogan, H., McKeown, P., Spillane, C., & Brychkova, G. (2024). Unravelling the Transcriptional Response of Agaricus bisporus under Lecanicillium fungicola Infection. International Journal of Molecular Sciences, 25, 1283. doi:10.3390/ijms25021283

Quiroz, L. F., Gondalia, N., Brychkova, G., McKeown, P. C., & Spillane, C. (2024). Haploid rhapsody: the molecular and cellular orchestra of haploid induction in plants. New Phytologist, 241(5), 1936-1949. doi:10.1111/nph.19523

Brychkova, G., de Oliveira, C. L., Gomes, L. A. A., Gomes, M. D., Fort, A., Esteves-Ferreira, A. A., . . . Spillane, C. (2023). Regulation of Carotenoid Biosynthesis and Degradation in Lettuce (Lactuca sativa L.) from Seedlings to Harvest. International Journal of Molecular Sciences, 24(12). doi:10.3390/ijms241210310

Dupouy, G., Cashell, R., Brychkova, G., Tuteja, R., McKeown, P. C., & Spillane, C. (2023). PICKLE RELATED 2 is a Neofunctionalized Gene Duplicate Under Positive Selection With Antagonistic Effects to the Ancestral PICKLE Gene on the Seed Transcriptome. Genome Biology and Evolution, 15(11). doi:10.1093/gbe/evad191

Lopez, F. B., McKeown, P. C., Fort, A., Brychkova, G., & Spillane, C. (2023). The boys are back in town: Rethinking the function of ribosomal DNA repeats in the genomic era. Molecular Plant, 16(3), 514-516. doi:10.1016/j.molp.2023.01.007

Brychkova, G., Kekae, K., McKeown, P. C., Hanson, J., Jones, C. S., Thornton, P., & Spillane, C. (2022). Climate change and land-use change impacts on future availability of forage grass species for Ethiopian dairy systems. Scientific Reports, 12(1). doi:10.1038/s41598-022-23461-w

Casey, L., Freeman, B., Francis, K., Brychkova, G., McKeown, P., Spillane, C., . . . Styles, D. (2022). Comparative environmental footprints of lettuce supplied by hydroponic controlled-environment agriculture and field-based supply chains. Journal of Cleaner Production, 369. doi:10.1016/j.jclepro.2022.133214

Castillo-Bravo, R., Fort, A., Cashell, R., Brychkova, G., McKeown, P. C., & Spillane, C. (2022). Parent-of-Origin Effects on Seed Size Modify Heterosis Responses in Arabidopsis thaliana. Frontiers in Plant Science, 13. doi:10.3389/fpls.2022.835219

Castillo-Bravo, R., Lucca, N., Lai, L. Y., Marlborough, K., Brychkova, G., Sakhteh, M. S., . . . Spillane, C. (2022). Clinical Performance of Direct RT-PCR Testing of Raw Saliva for Detection of SARS-CoV-2 in Symptomatic and Asymptomatic Individuals. Microbiology Spectrum, 10(6). doi:10.1128/spectrum.02229-22

Dupouy, G., McDermott, E., Cashell, R., Scian, A., McHale, M., Ryder, P., . . . Spillane, C. (2022). Plastid ribosome protein L5 is essential for post-globular embryo development in Arabidopsis thaliana. Plant Reproduction, 35(3), 189-204. doi:10.1007/s00497-022-00440-9

Hanley, A., Brychkova, G., Barbon, W. J., Noe, S. M., Myae, C., Thant, P. S., . . . Spillane, C. (2021). Community-Level Impacts of Climate-Smart Agriculture Interventions on Food Security and Dietary Diversity in Climate-Smart Villages in Myanmar. Climate, 9(11). doi:10.3390/cli9110166

Lopez, F. B., Fort, A., Tadini, L., Probst, A. V., McHale, M., Friel, J., . . . Spillane, C. (2021). Gene dosage compensation of rRNA transcript levels in Arabidopsis thaliana lines with reduced ribosomal gene copy number. Plant Cell, 33(4), 1135-1150. doi:10.1093/plcell/koab020

Vellinga, A., Mellotte, M., Mealy, P. J., Staines, A., O’Connor, P., Brychkova, G., & d’Aquin, M. (2021). Corona citizens’ science project-repeated surveys of the Irish response to COVID-19 and subsequent lockdown and restrictive measures. Irish Journal of Medical Science. doi:10.1007/s11845-021-02582-7

de Oliveira, C. L., Brychkova, G., Esteves-Ferreira, A. A., McKeown, P., Gomes, M. D., Maluf, W. R., . . . Spillane, C. (2020). Thermal disruption of the food matrix of biofortified lettuce varieties modifies absorption of carotenoids by Caco-2 cells. Food Chemistry, 308. doi:10.1016/j.foodchem.2019.125443

Hummel, M., Talsma, E. F., Taleon, V., Londono, L., Brychkova, G., Gallego, S., . . . Spillane, C. (2020). Iron, Zinc and Phytic Acid Retention of Biofortified, Low Phytic Acid, and Conventional Bean Varieties When Preparing Common Household Recipes. Nutrients, 12(3). doi:10.3390/nu12030658

Duszynska, D., Vilhjalmsson, B., Bravo, R. C., Swamidatta, S., Juenger, T. E., Donoghue, M. T. A., . . . Spillane, C. (2019). Transgenerational effects of inter-ploidy cross direction on reproduction and F2 seed development of Arabidopsis thaliana F1 hybrid triploids. Plant Reproduction, 32(3), 275-289. doi:10.1007/s00497-019-00369-6

Hallahan, B. F., Fernandez-Tendero, E., Fort, A., Ryder, P., Dupouy, G., Deletre, M., . . . Spillane, C. (2018). Hybridity has a greater effect than paternal genome dosage on heterosis in sugar beet (Beta vulgaris). Bmc Plant Biology, 18. doi:10.1186/s12870-018-1338-x

Hummel, M., Hallahan, B. F., Brychkova, G., Ramirez-Villegas, J., Guwela, V., Chataika, B., . . . Spillane, C. (2018). Reduction in nutritional quality and growing area suitability of common bean under climate change induced drought stress in Africa. Scientific Reports, 8. doi:10.1038/s41598-018-33952-4

Brychkova, G., Kurmanbayeva, A., Bekturova, A., Khozin, I., Standing, D., Yarmolinsky, D., & Sagi, M. (2017). Determination of Enzymes Associated with Sulfite Toxicity in Plants: Kinetic Assays for SO, APR, SiR, and In-Gel SiR Activity. Plant Stress Tolerance, 2 Edition, 1631, 229-251. doi:10.1007/978-1-4939-7136-7_14

Kumar, A. P. K., McKeown, P. C., Boualem, A., Ryder, P., Brychkova, G., Bendahmane, A., . . . Spillane, C. (2017). TILLING by Sequencing (TbyS) for targeted genome mutagenesis in crops. Molecular Breeding, 37(2). doi:10.1007/s11032-017-0620-1

Kurmanbayeva, A., Brychkova, G., Bekturova, A., Khozin, I., Standing, D., Yarmolinsky, D., & Sagi, M. (2017). Determination of Total Sulfur, Sulfate, Sulfite, Thiosulfate, and Sulfolipids in Plants. Plant Stress Tolerance, 2 Edition, 1631, 253-271. doi:10.1007/978-1-4939-7136-7_15

Srivastava, S., Brychkova, G., Yarmolinsky, D., Soltabayeva, A., Samani, T., & Sagi, M. (2017). Aldehyde Oxidase 4 Plays a Critical Role in Delaying Silique Senescence by Catalyzing Aldehyde Detoxification. Plant Physiology, 173(4), 1977-1997. doi:10.1104/pp.16.01939

Murray, U., Gebremedhin, Z., Brychkova, G., & Spillane, C. (2016). Smallholder Farmers and Climate Smart Agriculture: Technology and Labor-productivity Constraints amongst Women Smallholders in Malawi. Gender Technology & Development, 20(2), 117-148. doi:10.1177/0971852416640639

Babenko, O. N., Brychkova, G., Sagi, M., & Alikulov, Z. A. (2015). Molybdenum application enhances adaptation of crested wheatgrass to salinity stress. Acta Physiologiae Plantarum, 37(2). doi:10.1007/s11738-014-1757-8

Yarmolinsky, D., Brychkova, G., Kurmanbayeva, A., Bekturova, A., Ventura, Y., Khozin-Goldberg, I., . . . Sagi, M. (2014). Impairment in Sulfite Reductase Leads to Early Leaf Senescence in Tomato Plants. Plant Physiology, 165(4), 1505-1520. doi:10.1104/pp.114.241356

Brychkova, G., Grishkevich, V., Fluhr, R., & Sagi, M. (2013). An essential role for tomato Sulfite Oxidase and enzymes of the sulfite network in maintaining leaf sulfite homeostasis. Plant Physiology, 161(1), 148-164. doi:10.1104/pp.112.208660

Yarmolinsky, D., Brychkova, G., Fluhr, R., & Sagi, M. (2013). Sulfite Reductase Protects Plants against Sulfite Toxicity. Plant Physiology, 161(2), 725-743. doi:10.1104/pp.112.207712

Brychkova, G., Yarmolinsky, D., Fluhr, R., & Sagi, M. (2012). The determination of sulfite levels and its oxidation in plant leaves. Plant Science, 190, 123-130. doi:10.1016/j.plantsci.2012.04.004

Brychkova, G., Yarmolinsky, D., & Sagi, M. (2012). Kinetic Assays for Determining In Vitro APS Reductase Activity in Plants without the Use of Radioactive Substances. Plant and Cell Physiology, 53(9), 1648-1658. doi:10.1093/pcp/pcs091

Brychkova, G., Yarmolinsky, D., Ventura, Y., & Sagi, M. (2012). A Novel In-Gel Assay and an Improved Kinetic Assay for Determining In Vitro Sulfite Reductase Activity in Plants. Plant and Cell Physiology, 53(8), 1507-1516. doi:10.1093/pcp/pcs084

Moldakimova, N. A., Mukiyanova, G. S., Yarmolinsky, D. G., Brychkova, G. G., Scholthof, H. B., Sagi, M., & Omarov, R. T. (2012). Modulation of plant resistance to viral pathogen by abiotic stress factor. Phytopathology, 102(7), 81-81.

Brychkova, G., Alikulov, Z., Fiuhr, R., & Sagi, M. (2008). A critical role for ureides in dark and senescence-induced purine remobilization is unmasked in the Atxdh1 Arabidopsis mutant. Plant Journal, 54(3), 496-509. doi:10.1111/j.1365-313X.2008.03440.x

Brychkova, G., Xia, Z. L., Yang, G. H., Yesbergenova, Z., Zhang, Z. L., Davydov, O., . . . Sagi, M. (2007). Sulfite oxidase protects plants against sulfur dioxide toxicity. Plant Journal, 50(4), 696-709. doi:10.1111/j.1365-313X.2007.03080.x

Brychkova, G. G., Sorokin, A. P., & Kartel, N. A. (2004). Bioremediation with ecologically safe plants. Genomics for Biosafety in Plant Biotechnology, 359, 147-158. Retrieved from <Go to ISI>://WOS:000226185200013

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